MYELOID NEOPLASIA T-cell immune responses to Wilms tumor 1 protein in myelodysplasia responsive to immunosuppressive therapy
نویسندگان
چکیده
1Hematology Branch, National Heart, Lung and Blood Institute, 2Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, and 3Office of Biostatistics Research, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD; 4Cardiff University School of Medicine, Cardiff, Wales; and 5Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD
منابع مشابه
T-cell immune responses to Wilms tumor 1 protein in myelodysplasia responsive to immunosuppressive therapy.
Clinical observations and laboratory evidence link bone marrow failure in myelodysplastic syndrome (MDS) to a T cell-mediated immune process that is responsive to immunosuppressive treatment (IST) in some patients. Previously, we showed that trisomy 8 MDS patients had clonally expanded CD8(+) T-cell populations that recognized aneuploid hematopoietic progenitor cells (HPC). Furthermore, microar...
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